BDBM50063719 2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-one::CHEMBL10756

SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1

InChI Key InChIKey=KYGGCZMWHBADHK-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 Koff  1 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50063719   

TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against human cytomegalovirus protease variant expressing a beta galactosidase reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using Cbz-Gly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataIC50: 33nMAssay Description:Inhibitory concentration against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKon:  0.0000180M-1s-1Assay Description:Rate of deacylation by human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2010
Entry Details Article
PubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against human chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2010
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKi:  1.58nM Kon:  0.0000178M-1s-1 Koff:  1.18E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed