BDBM50063703 2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one::CHEMBL10378

SMILES Ic1ccccc1-c1nc2ccccc2c(=O)o1

InChI Key InChIKey=VEBIXPCJYGGBAF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50063703   

TargetKallikrein-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 9.89E+3nMAssay Description:Compound was evaluated for inhibitory activity against Kallikrein.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using Cbz-Gly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.53E+4nMAssay Description:Concentration of compound required to inhibit 50% trypsin derived from bovine pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 5.00E+4nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using Cbz-Gly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.53E+4nMAssay Description:Compound was evaluated for inhibitory activity against Trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 510nMAssay Description:Compound was evaluated for inhibitory activity against Thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 6.68E+3nMAssay Description:Compound was evaluated for inhibitory activity against plasmin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1s subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.25E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1s serine protease. More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 5.00E+4nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease in assay 2 at t=60 min.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.37E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease. More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetComplement C1r subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50: 1.40E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease in assay 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article