BDBM50063405 2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone::CHEMBL171443

SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccc(Br)cc3)c3ncccc3CCc2c1

InChI Key InChIKey=DNMVTJNZEPUZGW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50063405   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063405(2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063405(2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50: 2.04E+3nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50063405(2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of rat Geranylgeranyl transferase (GGPT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed