BDBM50063137 (R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-butyric acid::CHEMBL160153

SMILES CSc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O

InChI Key InChIKey=CTGTUEAFFDISNJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50063137   

TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 5.90nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063137((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed