BDBM50062407 5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL430855

SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cccc(Br)c4)c3c12

InChI Key InChIKey=YPUGASLTKIAOPT-UHFFFAOYSA-N

Data  3 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50062407   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataIC50: 1.14E+3nMAssay Description:Antagonistic activity was determined in Human progesterone receptor(hPR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataIC50: 266nMAssay Description:Antagonistic activity was determined in Human glucocorticoid receptor(hGR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataEC50:  8nMAssay Description:Agonistic activity to the human progesterone receptor (hPR)assayed in CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataIC50: 401nMAssay Description:Antagonistic activity was determined in Human androgen receptor(hAR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataIC50: 1.07E+3nMAssay Description:Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  1.10nMAssay Description:The binding affinity on Human progesterone receptor (hPR-A) using progesterone as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  34nMAssay Description:Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062407(5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  2.14E+3nMAssay Description:Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed