BDBM50061620 CHEMBL3394071::US9321756, 210

SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(N)n3)c2c1

InChI Key InChIKey=NVEXZMGIURASMO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50061620   

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 28.7nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 142nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 192nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 142nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061620(CHEMBL3394071 | US9321756, 210)
Affinity DataIC50: 192nMAssay Description:Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed