BDBM50061559 CHEMBL72292::Trifluoro-methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-yl ester

SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(OS(=O)(=O)C(F)(F)F)cc12

InChI Key InChIKey=XKXPMSXRABANAG-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50061559   

TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 64nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 34nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 31nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 47nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 53nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 31nMAssay Description:Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 140nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 34nMAssay Description:Binding affinity towards 5-HT2C receptor from rat using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 120nMAssay Description:Binding affinity towards human D4.2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of binding of 1.0 nM [3H]pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 47nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 43nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 64nMAssay Description:Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed