BDBM50061557 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol::CHEMBL70377

SMILES CN1CCN(CC1)C1=Nc2cc(O)ccc2Nc2ccccc12

InChI Key InChIKey=JLYQCLIQUFEFFL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50061557   

Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 310nMAssay Description:Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 440nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 27nMAssay Description:Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 440nMAssay Description:Binding affinity towards 5-HT2C receptor from rat using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 6.40E+3nMAssay Description:Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 310nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 27nMAssay Description:Inhibition of binding of 1.0 nM [3H]pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50061557(11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]d...)
Affinity DataIC50: 9.80E+3nMAssay Description:Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed