BDBM50060441 3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indole::CHEMBL324931

SMILES CN1CCN(CCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1

InChI Key InChIKey=YOIQHSYPJYUDKZ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50060441   

Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataEC50:  80nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataIC50: 310nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataEC50:  105nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataIC50: 304nMAssay Description:Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060441(3-[2-(4-Methyl-piperazin-1-yl)-ethyl]-5-[1,2,4]tri...)
Affinity DataIC50: 134nMAssay Description:Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed