BDBM50059875 (S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phosphono-tetradeca-4,8,12-trienoylamino)-propionic acid::CHEMBL26236

SMILES [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]-[#6]=[#6](-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O)P([#8])([#8])=O

InChI Key InChIKey=KVQLDTKCTCUYNQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059875   

LigandPNGBDBM50059875((S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phospho...)
Affinity DataIC50: 83nMAssay Description:In vitro inhibition of bovine Farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50059875((S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phospho...)
Affinity DataIC50: 80nMAssay Description:Activity against bovine FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50059875((S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phospho...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of squalene synthase from rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50059875((S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phospho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of farnesylation of H-Ras in DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50059875((S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phospho...)
Affinity DataIC50: 80nMAssay Description:Inhibition of farnesyl protein transferase from bovine brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article