BDBM50059860 ((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphonic acid::CHEMBL26180::Hydroxy phosphonate, 1

SMILES [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6](=O)P([#8])([#8])=O

InChI Key InChIKey=DTKKIBZEICDNGH-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059860   

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50059860(CHEMBL26180 | Hydroxy phosphonate, 1 | ((2E,6E)-1-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of squalene synthase from rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50059860(CHEMBL26180 | Hydroxy phosphonate, 1 | ((2E,6E)-1-...)
Affinity DataIC50: 410nMAssay Description:Inhibition of farnesyl protein transferase from bovine brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetFarnesyl pyrophosphate synthase(Human)
Merck Research Laboratories

LigandPNGBDBM50059860(CHEMBL26180 | Hydroxy phosphonate, 1 | ((2E,6E)-1-...)
Affinity DataKi:  4.70nMAssay Description:Assay using farnesyl-ras-CVLS as the protein acceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Merck Research Laboratories

LigandPNGBDBM50059860(CHEMBL26180 | Hydroxy phosphonate, 1 | ((2E,6E)-1-...)
Affinity DataKi:  5.20nMAssay Description:FPTase activity was assayed in the biosynthetically forward direction at 30C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2013
Entry Details Article
PubMed
LigandPNGBDBM50059860(CHEMBL26180 | Hydroxy phosphonate, 1 | ((2E,6E)-1-...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity against farnesyl pyrophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed