BDBM50059717 4-(furan-3-yl)-7-((6-(4-hydroxytetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)-2-naphthonitrile::4-Furan-3-yl-7-[6-(4-hydroxy-tetrahydro-pyran-4-yl)-pyridin-2-ylmethoxy]-naphthalene-2-carbonitrile::CHEMBL99217

SMILES OC1(CCOCC1)c1cccc(COc2ccc3c(cc(cc3c2)C#N)-c2ccoc2)n1

InChI Key InChIKey=NXWSHKALJVLTCA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059717   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50059717(4-Furan-3-yl-7-[6-(4-hydroxy-tetrahydro-pyran-4-yl...)
Affinity DataIC50: 15nMAssay Description:Compound was evaluated for the potency to inhibit oxidation of arachidonic acid by human recombinant 5-Lipoxygenase using a spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50059717(4-Furan-3-yl-7-[6-(4-hydroxy-tetrahydro-pyran-4-yl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed