BDBM50059453 CHEMBL3393455

SMILES c1ccc(c(c1)[C@H]2c3c[nH]nc3NC4=C2C(=O)CNC4)F

InChI Key InChIKey=ITULOGMVDYUWCK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059453   

TargetAurora kinase A(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059453(CHEMBL3393455)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50059453(CHEMBL3393455)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of p-38 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059453(CHEMBL3393455)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059453(CHEMBL3393455)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TIE-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059453(CHEMBL3393455)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed