BDBM50059451 CHEMBL3393482

SMILES CCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5c(O)cccc5[nH]4)o3)C3=C(CCCC3=O)Nc12

InChI Key InChIKey=KPFKBJLOCNHHJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50059451   

TargetAurora kinase B(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059451(CHEMBL3393482)
Affinity DataIC50: 8nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059451(CHEMBL3393482)
Affinity DataIC50: 25nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059451(CHEMBL3393482)
Affinity DataIC50: 490nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase/human b5 reductase using 7-benzyloxyquinoline substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed