BDBM50059174 CHEMBL3393295

SMILES O=C(NCc1cccnc1)c1ccc(Oc2ccccc2C#N)cc1

InChI Key InChIKey=KDXXYHDZDWLQGL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059174   

TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059174(CHEMBL3393295)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of p38-alpha in human TC28 cells assessed as inhibition of IL-1-induced PGE2 production incubated for 20 mins prior to IL-1 challenge meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059174(CHEMBL3393295)
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MK2 (46 to 400) as substrate assessed as inhibition of phosphorylation after 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059174(CHEMBL3393295)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MSK1 as substrate assessed as inhibition of phosphorylation after 60 mins by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059174(CHEMBL3393295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059174(CHEMBL3393295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-alpha (unknown origin) by p38alpha-MBP IoC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed