BDBM50058911 CHEMBL63887::[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid

SMILES NC(=N)c1ccc(COc2ccc3C(=O)N(CC(O)=O)CCc3c2)cc1

InChI Key InChIKey=RQZOEJHWHDUMIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50058911   

TargetIntegrin alpha-IIb/beta-3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058911([6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1...)
Affinity DataIC50: 600nMAssay Description:Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058911([6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1...)
Affinity DataIC50: 600nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta-3 integrin (GP IIb-IIIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058911([6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1...)
Affinity DataIC50: 600nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta-3 integrin by 50% in an ELISA testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetIntegrin alpha-IIb/beta-3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058911([6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article