BDBM50058747 CHEMBL3327007

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(cc1)C(F)(F)F)-c1cnc2nc(N)nc(C)c2c1

InChI Key InChIKey=KQEBASQDUJBNAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50058747   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50058747(CHEMBL3327007)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate preincubated for 15 mins before substrate addition by luciferase-based luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50058747(CHEMBL3327007)
Affinity DataIC50: 67nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition of 4EBP-1 phosphorylation preincubated for 15 mins before substrate addition by TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed