BDBM50058640 CHEMBL61752::N-hydroxy-N-[(2E)-3-(5-methyl-2-furyl)prop-2-enyl]urea

SMILES Cc1ccc(\C=C\CN(O)C(N)=O)o1

InChI Key InChIKey=IYXXVVRCYVZFNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50058640   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50058640(N-hydroxy-N-[(2E)-3-(5-methyl-2-furyl)prop-2-enyl]...)
Affinity DataIC50: 160nMAssay Description:Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50058640(N-hydroxy-N-[(2E)-3-(5-methyl-2-furyl)prop-2-enyl]...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed