BDBM50057775 CHEMBL3323003::US9598387, Compound 127::US9969743, 127

SMILES O=C(NCCCCN1CCN(CC1)c1ncnc2ccccc12)c1cn2ccccc2n1

InChI Key InChIKey=HISGEOZMKTZBBP-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50057775   

TargetD(3) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataIC50: 409nMAssay Description:Antagonist activity against D3R in human U2OS cells assessed as inhibition of (+)-PD128907-induced beta-arrestin translocation by beta-galactosidase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataIC50: 248nMAssay Description:Antagonist activity against human D2LR expressed in CHOK1 cells assessed as inhibition of pergolide-induced beta-arrestin translocation by beta-galac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataIC50: 940nMAssay Description:Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs by [3H]thymidine u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  253nMAssay Description:Displacement of [125I]IABN from human D3R expressed in HEK293 cell membranes by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  253nMAssay Description:The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  253nMAssay Description:Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  1.13E+3nMAssay Description:Displacement of [125I]IABN from human D2LR expressed in HEK293 cell membranes by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  1.13E+3nMAssay Description:The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057775(CHEMBL3323003 | US9598387, Compound 127 | US996974...)
Affinity DataKi:  1.13E+3nMAssay Description:Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent