BDBM50057155 (Z)-2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl)-4-oxo-but-2-enoate(2-hydroxy-ethyl)-trimethyl-ammonium;::CHEMBL10801::CHEMBL51530

SMILES COc1ccc(cc1)C(=O)C(\Cc1ccccc1)=C(/C([O-])=O)c1ccc2OCOc2c1

InChI Key InChIKey=VJWJTNIBNOJJIE-UHFFFAOYSA-M

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50057155   

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 4.55E+3nMAssay Description:Binding affinity for human endothelin B receptor expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 7.40nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of Endothelin B receptor mediated (ET-3) release of arachidonic acid from human cloned receptors expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 49nMAssay Description:Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Merck

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 4.55E+3nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50057155(CHEMBL51530 | CHEMBL10801 | (Z)-2-Benzo[1,3]dioxol...)
Affinity DataIC50: 7.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed