BDBM50056945 4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-ethyl}-benzamide::CHEMBL177031

SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12

InChI Key InChIKey=FGNDDXTVXSKQJK-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50056945   

Target5-hydroxytryptamine receptor 1A(Rat)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 75nMAssay Description:Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  120nMAssay Description:Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  480nMAssay Description:Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  650nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid PlexusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  650nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid PlexusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056945(4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed