BDBM50056508 CHEMBL3341945

SMILES COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=SJOCBUINMBQCTH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056508   

TargetActivin receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 186nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 100nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 16nMAssay Description:Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 27nMAssay Description:Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetActivin receptor type-1(Mouse)
Massachusetts Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50056508(CHEMBL3341945)
Affinity DataIC50: 4nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed