BDBM50056247 (6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13-octahydro-5H-8-aza-benzocycloundecene-9-carboxylic acid::CHEMBL346424

SMILES OC(=O)[C@@H]1CCCCc2ccccc2C[C@@H](CS)C(=O)N1

InChI Key InChIKey=MCEAHFJYQBFRCJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50056247   

TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 7nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration required to inhibit Angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed