BDBM50055936 CHEMBL3321926::US9884814, Compound 25

SMILES COc1ccc(CNC(=O)[C@@H](CC2CCCCC2)NC(=N)NC(=O)Cc2ccc(OC)c(OC)c2)cc1OC

InChI Key InChIKey=JBDHGEVVWPHZDD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50055936   

TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055936(CHEMBL3321926 | US9884814, Compound 25)
Affinity DataIC50: 120nMAssay Description:Inhibition of human liver cathepsin D using MCA-labeled GKPILFFRLK(Dnp)-D-R-NH2 peptide by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055936(CHEMBL3321926 | US9884814, Compound 25)
Affinity DataIC50: 120nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent