BDBM50055896 3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-propionic acid; TFA::CHEMBL141632::CHEMBL22599

SMILES NC(=N)c1ccc(cc1)C1=NOC(CC(=O)NCCC(O)=O)C1

InChI Key InChIKey=NENLGQJHPDXGES-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50055896   

TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Fibrinogen Receptor integrin alphaIIb-beta3 in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of VLA-4 integrin alpha4-beta1 interaction with VCAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-M/beta-2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Mac-1 integrin (alphaM-beta2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of interaction between HUVEC cells and fibronectinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-M/beta-2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Mac-1 interaction with ICAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 240nMAssay Description:Inhibition of platelet aggregation in citreated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 1.10nMAssay Description:Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 560nMAssay Description:Inhibition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 140nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 240nMAssay Description:In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 60nMAssay Description:Inhibition of platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 240nMAssay Description:Inhibition of platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 112nMAssay Description:Inhibition of Platelet glycoprotein IIb/Platelet glycoprotein IIIa binding in unactivated human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(CHEMBL22599 | CHEMBL141632 | 3-{2-[3-(4-Carbamimid...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GPIIb/IIIa binding in activated human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed