BDBM50055569 CHEMBL46937::[2-(4-Butyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

SMILES CCCCc1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=JMSHBDSUSOGKTP-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50055569   

TargetEstrogen receptor beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055569([2-(4-Butyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-y...)
Affinity DataIC50: 10nMAssay Description:Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-est...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50055569([2-(4-Butyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-y...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to ERalpha ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50055569([2-(4-Butyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-y...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50055569([2-(4-Butyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-y...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]estradiol from ERbeta after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed