BDBM50055498 CHEMBL3326004::US10004755, Compound UNC1669A::US9795606, B28

SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1

InChI Key InChIKey=DCFNMFYAKVXCLN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50055498   

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 250nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Flt3 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Axl (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of Tyro3 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 33nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 22nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent