BDBM50055496 CHEMBL3326006
SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
InChI Key InChIKey=MJSHVHLADKXCML-UHFFFAOYSA-N
Data 27 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50055496
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGFR extracellular/transmembrane domain-tagged Mer intracellular domain (unknown origin) expressed in 32D cells assessed as inhibition ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of N-terminal GST-tagged human TRKC cytoplasmic domain (456 to 825 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged full length human NuaK1 (1 to 661 end residues) expressed in baculovirus expression system using fluorecence-labe...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged human AXL cytoplasmic domain (464 to 885 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged full length human QIK (1 to 926 end residues) expressed in baculovirus expression system using fluorecence-labele...More data for this Ligand-Target Pair
TargetSTE20-like serine/threonine-protein kinase(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of N-terminal GST-tagged full length human SLK (1 to 1152 end residues) expressed in baculovirus expression system using fluorecence-label...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of N-terminal GST-tagged human KIT cytoplasmic domain (544 to 976 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged human TYRO3 cytoplasmic domain (453 to 890 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
Affinity DataIC50: 301nMAssay Description:Inhibition of EGFR extracellular/transmembrane domain-tagged Tyro3 intracellular domain (unknown origin) expressed in 32D cells assessed as inhibitio...More data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Inhibition of EGFR extracellular/transmembrane domain-tagged Axl intracellular domain (unknown origin) expressed in 32D cells assessed as inhibition ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Flt3 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Flt3 phosphorylation in human Molm-14 cells preincubated for 1 hr by densitometryMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Mer phosphorylation in human 697 cells preincubated for 1 hr by densitometryMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 364nMAssay Description:Inhibition of Met (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of Kit (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Nuak1 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetSTE20-like serine/threonine-protein kinase(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of SLK (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of QIK (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of TRKC (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Human)
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Unc Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TRKA (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of Tyro3 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Axl (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 0.740nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair