BDBM50055004 7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]diazepino[2,1-a]isoindol-7-ol::CHEMBL130255

SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)cc1

InChI Key InChIKey=HIQMOURJGWXAGS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50055004   

TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055004(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055004(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Affinity DataIC50: 2.70nMAssay Description:Compound was tested for inhibition of [3H]WIN-35428 binding at the dopamine transporter in brain from guinea pig striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055004(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Affinity DataIC50: 1.25E+3nMAssay Description:Compound was tested for inhibition of [3H]citalopram binding at the serotonin transporter in rat fore brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055004(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055004(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Affinity DataIC50: 1.5nMAssay Description:Ability to displace [3H]WIN-35428 from dopamine transporter in rat caudate putamen tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed