BDBM50054405 CHEMBL3319358::US9522881, 11a-3 (L97M50)::US9844535, ID 11a-3 (L97M50)

SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(OCc3ccccc3)c(Cl)c2)c1

InChI Key InChIKey=UTBADYWVJGFMEB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50054405   

TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
Indiana University Research and Technology

US Patent
LigandPNGBDBM50054405(US9522881, 11a-3 (L97M50) | CHEMBL3319358 | US9844...)
Affinity DataIC50: 660nMpH: 7.0Assay Description:The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50054405(US9522881, 11a-3 (L97M50) | CHEMBL3319358 | US9844...)
Affinity DataIC50: 660nMAssay Description:Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
Indiana University Research and Technology

US Patent
LigandPNGBDBM50054405(US9522881, 11a-3 (L97M50) | CHEMBL3319358 | US9844...)
Affinity DataIC50: 660nMAssay Description:PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent