BDBM50053631 2-(4-Methyl-piperazin-1-yl)-quinoline::2-(4-methylpiperazin-1-yl)quinoline::CHEMBL288591

SMILES CN1CCN(CC1)c1ccc2ccccc2n1

InChI Key InChIKey=HOMWNUXPSJQSSU-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50053631   

Target5-hydroxytryptamine receptor 3A(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  0.457nMAssay Description:Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  3nMAssay Description:Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  3nMAssay Description:Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  410nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma-S-AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50053631(2-(4-methylpiperazin-1-yl)quinoline | 2-(4-Methyl-...)
Affinity DataKi:  6.92E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed