BDBM50053305 CHEMBL3330409

SMILES CCc1ccccc1C(N(C)C)C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)S(N)(=O)=O)c2c1

InChI Key InChIKey=JAHXQCZCZURPTI-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50053305   

TargetSerine/threonine-protein kinase PLK1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 83nMAssay Description:Inhibition of GST-tagged human PLK4 (1-391 residues) phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 400nMAssay Description:Inhibition of Aurora A (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 480nMAssay Description:Inhibition of Aurora B (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 420nMAssay Description:Inhibition of CHK2 (unknown origin) by FRET-based homogenous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 in supersomes (unknown origin) using Dibenzylfluorescein as substrate after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP3A4 in supersomes (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SUMO-tagged human TTK (1-275 residues) compound pre-incubated for 15 mins prior ATP addition by MBP-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP2C19 in supersomes (unknown origin) using MFC as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2C9 in supersomes (unknown origin) using MFC as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in supersomes (unknown origin) using CEC as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 in supersomes (unknown origin) using AMMC as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50053305(CHEMBL3330409)
Affinity DataEC50:  520nMAssay Description:Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed