BDBM50051924 CHEMBL32754::N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES COc1cc(OC)c(CNc2cnc3nc(N)nc(N)c3c2)c(OC)c1

InChI Key InChIKey=RURZOOLNQASAMS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051924   

TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 230nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051924(N*6*-(2,4,6-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 230nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed