BDBM50051913 CHEMBL32113::N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3-d]pyrimidine-2,4,6-triamine::N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE::N6-(2,5-dimethoxybenzyl)-N6-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES C[N@](Cc1cc(ccc1OC)OC)c2cc3c(nc(nc3nc2)N)N

InChI Key InChIKey=HZTFNSCZLJLPEO-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50051913   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Shandong First Medical University and Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 57nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 84nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 57nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 84nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 84nMAssay Description:Inhibition of dihydrofolate reductase from pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 57nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Shandong First Medical University and Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Shandong First Medical University and Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 84nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against recombinant sf dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 6.30nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 57nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibitory activity against recombinant lc dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051913(N*6*-(2,5-Dimethoxy-benzyl)-N*6*-methyl-pyrido[2,3...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against recombinant ec dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed