BDBM50051901 1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-3,5-dimethyl-1H-pyrazole::CHEMBL33780
SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
InChI Key InChIKey=UUPITLNVYVCTFW-UHFFFAOYSA-N
Data 26 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50051901
Affinity DataIC50: 90nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell cultureMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from cholesterol fed rabbit liverMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit arteryMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from pig liverMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from human liverMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset gutMore data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit gutMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset adrenalMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rat liverMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicateMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Concentration required for the inhibition of ACAT from rat gutMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit adrenal.More data for this Ligand-Target Pair
Affinity DataIC50: 108nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit intestine.More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit liver.More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:cholesterol acyltransfer...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholesterol acyltransfe...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit artery.More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from hamster liverMore data for this Ligand-Target Pair