BDBM50051829 4-methyl-2-oxo-2H-chromen-7-yl sulfamate::CHEMBL11185::Sulfamic acid 4-methyl-2-oxo-2H-chromen-7-yl ester

SMILES Cc1cc(=O)oc2cc(OS(N)(=O)=O)ccc12

InChI Key InChIKey=UFGBGFMPBMEVMI-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50051829   

TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Inhibition of STS activity in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Inhibitory activity against estrone sulfatase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against Estrone SulfataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of estrone sulfatase (ES)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Tested for the inhibitory activity against Estrone SulfataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of estrone sulfatase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Estrone sulfataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of estrone sulfataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Inhibitory activity against Estrone sulfatase (E1-STS) in MCF-7 breast cancer cells at 0.1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its inhibitory activity against estrone sulfatase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Inhibition of placental microsomal steroid sulfatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 30nMAssay Description:Inhibition of steroid sulfatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataIC50: 380nMAssay Description:Inhibition of STS in human MCF7 cells assessed as reduction in [3H]estradiol and [3H]estrone formation using [3H]estrone sulfate as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50051829(4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Sulfami...)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human cytosolic isozyme CA IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed