BDBM50051408 CHEMBL3337527::US11071729, Compound 2

SMILES CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)c3ccccc3

InChI Key InChIKey=HYOGJHCDLQSAHX-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051408   

TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataIC50: 68nMAssay Description:Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataEC50:  147nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataEC50:  65nMAssay Description:Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataEC50:  147nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataEC50:  182nMAssay Description:Measurement of mGluR2 positive allosteric modulatory activity of test compounds in membranes containing human mGluR2 was performed using frozen membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)