BDBM50051340 2'-Hydroxyflavanone::2'-hydroxy-flavanone::2-(2-Hydroxy-phenyl)-chroman-4-one::2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one::CHEMBL75897

SMILES Oc1ccccc1C1CC(=O)c2ccccc2O1

InChI Key InChIKey=KZKWCKFDCPVDFJ-UHFFFAOYSA-N

Data  5 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50051340   

TargetAldo-keto reductase family 1 member C3(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AKR1C3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 6.40E+3nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced cell growth treated for every 2 days for 4 days by hemocytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced transcriptional activation after 24 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)TBA
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 149nMAssay Description:Inhibition of AchE in Rattus norvegicus (rat) cortex homogenates by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetAldo-keto reductase family 1 member C3(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 (D3) using oracin as substrate measured after 30 mins in presence of NADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant His-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) incubated for 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Oncowitan

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK-293 cells incubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataKi:  2.63E+3nMAssay Description:Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataKi:  2.64E+3nMAssay Description:Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataKi:  6.03E+3nMAssay Description:Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataKi:  6.07E+3nMAssay Description:Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50051340(2-(2-Hydroxy-phenyl)-chroman-4-one | 2'-Hydroxyfla...)
Affinity DataKi:  1.78E+4nMAssay Description:Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed