BDBM50051306 (3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine::CHEMBL72393

SMILES Brc1cccc(Nc2ncnc3[nH]c4CCCCc4c23)c1

InChI Key InChIKey=IVQMCCDVGIYFDZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50051306   

TargetEpidermal growth factor receptor(Human)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: 46nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: 400nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of tyrosine kinase c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed