BDBM50050420 6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23416

SMILES Cc1c(CNc2ccc(Cl)cc2)cnc2nc(N)nc(N)c12

InChI Key InChIKey=SOEDHSVWTZWFIM-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50050420   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 19nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 55.4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii(pc)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 51nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 27nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 0.840nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex dihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 55.4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050420(6-[(4-Chloro-phenylamino)-methyl]-5-methyl-pyrido[...)
Affinity DataIC50: 51nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed