BDBM50050417 6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL284544

SMILES COc1ccc(OC)c(CCc2cnc3nc(N)nc(N)c3c2C)c1

InChI Key InChIKey=VRAFZGTXFNQHGJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50050417   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 7.90nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 770nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 2.70E+3nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 47nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex dihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 7.90nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050417(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-pyrido...)
Affinity DataIC50: 770nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed