BDBM50050387 6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL22924

SMILES Nc1nc(N)c2cc(CNc3cccc4ccccc34)cnc2n1

InChI Key InChIKey=BBVNYSAAUUALLQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50050387   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 260nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 230nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 86nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex dihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 820nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 70nMAssay Description:Inhibition of dihydrofolate reductase from pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 96nMAssay Description:Inhibition of dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050387(6-(Naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 600nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed