BDBM50050087 CHEMBL3317840::US9216988, 50

SMILES CC(C)N(Cc1ccc(cc1)N1CCN(CC1)C(C)=O)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=QBHMBDZJVDBYGI-UHFFFAOYSA-N

Data  1 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50050087   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataIC50: 95nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50:  410nMAssay Description:Agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50:  37nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at GAL4-fused human RORb expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human FXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dua...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50050087(US9216988, 50 | CHEMBL3317840)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed