BDBM50049808 CHEMBL127968::N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)-ethyl]-4-fluoro-benzamide

SMILES CN1C(CCNC(=O)c2ccc(F)cc2)CN=C(c2ccccc2)c2cc(Cl)ccc12

InChI Key InChIKey=FLRKSGDCJCTWFD-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50049808   

TargetKappa-type opioid receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity against opioid receptor kappa 1 from human cloned receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity against Opioid receptor kappa 1 of guinea pig using [3H]U-65693 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity determined against Opioid receptor kappa 1 from a native receptor in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  4.74nMAssay Description:Binding affinity determined against Opioid receptor kappa 1 from a native receptor in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  53nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049808(N-[2-(7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-be...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against Opioid receptor delta 1 using [3H]DADLE as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed