BDBM50049418 CHEMBL3315275::US11401286, Example 59

SMILES CCc1nc(Nc2ccc(cc2)C(C)C(O)=O)nc(n1)-c1cccc(Cl)c1

InChI Key InChIKey=OFISQNBGNCPVKB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50049418   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50049418(CHEMBL3315275 | US11401286, Example 59)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50049418(CHEMBL3315275 | US11401286, Example 59)
Affinity DataIC50: 96nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50049418(CHEMBL3315275 | US11401286, Example 59)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50049418(CHEMBL3315275 | US11401286, Example 59)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50049418(CHEMBL3315275 | US11401286, Example 59)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent