BDBM50049236 (+/-)-1-Phosphono-4-(3-phenoxyphenyl)butylsulfonic Acid Tripotassium Salt::CHEMBL351151::Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosphono-butane-1-sulfonic acid::potassium salt of 4-(3-Phenoxy-phenyl)-1-phosphono-butane-1-sulfonic acid

SMILES [O-]P([O-])(=O)C(CCCc1cccc(Oc2ccccc2)c1)S([O-])(=O)=O

InChI Key InChIKey=RCGCZPXSRLLKCK-UHFFFAOYSA-K

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50049236   

TargetSqualene synthase(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataIC50: 169nMAssay Description:Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]FPP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Staphylococcus aureus dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataIC50: 83nMAssay Description:Inhibition of Staphylococcus aureus ATCC 27659 full length His-tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataIC50: 110nMAssay Description:Inhibition of CrtM in Staphylococcus aureus assessed as reduction in staphyloxanthin levels after 72 hrs by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of Staphylococcus aureus ATCC 27659 histidine-tagged full length CrtM expressed in Escherichia coli BL21(DE3) cells assessed as decrease i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2019
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50049236(Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of Staphylococcus aureus CrtMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed