BDBM50048507 CHEMBL299169::[(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-oxo-azepan-1-yl]-acetic acid

SMILES OC(=O)CN1CCCC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O

InChI Key InChIKey=DDYFSJLRMHFOPK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048507   

TargetAngiotensin-converting enzyme(Rabbit)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme isolated from rabbit lung extract.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 82nMAssay Description:In vitro inhibition of purified rat kidney Neutral endopeptidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 82nMAssay Description:In vitro inhibitory activity against purified rat kidney neutral endopeptidase (NEP) using a fluorometric assay with dansyl-Gly-Phe-Arg as the substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzyme (ACE) isolated from rabbit lung extract using hippuryl-L-histidyl-L-leucine (HHL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 82nMAssay Description:Inhibition of Neutral Endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

TargetAngiotensin-converting enzyme(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50048507([(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article