BDBM50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489

SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1

InChI Key InChIKey=ROKDRQZSBSPKDT-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50048047   

TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048047(2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyr...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048047(2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyr...)
Affinity DataIC50: 640nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048047(2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyr...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of purine nucleoside phosphorylase from calf spleen in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048047(2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyr...)
Affinity DataKi:  333nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048047(2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyr...)
Affinity DataKi:  335nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed