BDBM50046473 8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadeca-2(10),3,5,7-tetraen-15-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione::CHEMBL285203

SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12

InChI Key

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50046473   

TargetSigma non-opioid intracellular receptor 1(Human)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50046473(8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]penta...)
Affinity DataIC50: 54nMAssay Description:Binding affinity against sigma sites in guinea pig membrane using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50046473(8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]penta...)
Affinity DataIC50: 988nMAssay Description:Binding affinity against sigma sites in guinea pig membrane using [3H](+)-3-PPP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A/2B/2C(Mouse)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50046473(8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]penta...)
Affinity DataKi:  2.26E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50046473(8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]penta...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity against D2 receptor in rat corpus striatum using [3H]sulpiride as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50046473(8-{4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]penta...)
Affinity DataKi:  3.01E+3nMAssay Description:Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]sulpirideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed