BDBM50045625 CHEMBL3314305::US9540323, 198::US9540323, example 198

SMILES CC1(C)CN(c2c1c(ccc2O)-c1ccc(F)cc1)c1ccccc1NC(=O)Nc1csc(Cl)n1

InChI Key InChIKey=XYQCJYPMADYTIQ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50045625   

TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045625(US9540323, 198 | CHEMBL3314305 | US9540323, exampl...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 10 uM ADP-induced platelet aggregation preincubated for 1 min foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045625(US9540323, 198 | CHEMBL3314305 | US9540323, exampl...)
Affinity DataIC50: 0.0300nMAssay Description:Antagonist activity at P2Y1 receptor in washed human platelets assessed as 1 uM 2-methylthio-ADP-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045625(US9540323, 198 | CHEMBL3314305 | US9540323, exampl...)
Affinity DataKi:  4.90nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent